Envelope diversity, characteristics of V3 region and predicted co-receptor usage of human immunodeficiency viruses infecting north indians |
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Authors: | Raiees Andrabi Rajesh Kumar Manju Bala Ambili Nair Prakash SS Vandana Kushwaha Kalpana Luthra |
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Affiliation: | 1. Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India 2. Regional STD Teaching Training & Research Centre, Safdarjung Hospital, New Delhi, India
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Abstract: | Subtypes of human immunodeficiency virus type 1 circulating in 21 north Indian patients were characterized based on the partial sequence of the gp120 envelope protein. A majority of viruses (85.7%, 18/21) were subtype C, while 14.3% (3/21) were subtype A. Sequence analysis revealed that the V3 region was highly conserved compared with V4 and V5. The predicted use of co-receptors indicated exclusive usage of R5, except for two subtype A viruses (AIIMS279 and AIIMS281). Our results demonstrate conservation within the V3 loop of subtype C viruses, and suggest the emergence of non-clade C viruses in the north Indian population. |
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