Resident mesenchymal progenitors of articular cartilage |
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| Affiliation: | 1. Translational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, Department of Surgery, Children''s Hospital of Philadelphia, Philadelphia, PA, USA;2. Division of Pathology, Department of Diagnostic Science, School of Dentistry, Showa University, Tokyo, Japan;3. McKay Orthopaedic Research Laboratory, Perleman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA |
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| Abstract: | Articular cartilage has poor capacity of self-renewal and repair. Insufficient number and activity of resident mesenchymal (connective tissue) progenitors is likely one of the underlying reasons. Chondroprogenitors reside not only in the superficial zone of articular cartilage but also in other zones of articular cartilage and in the neighboring tissues, including perichondrium (groove of Ranvier), synovium and fat pad. These cells may respond to injury and contribute to articular cartilage healing. In addition, marrow stromal cells can migrate through subchondral bone when articular cartilage is damaged. We should develop drugs and methods that correctly stimulate resident progenitors for improvement of repair and inhibition of degenerative changes in articular cartilage. |
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