Compounds from Kadsura heteroclita and related anti-HIV activity |
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| Authors: | Pu Jian-Xin Yang Liu-Meng Xiao Wei-Lie Li Rong-Tao Lei Chun Gao Xue-Mei Huang Sheng-Xiong Li Sheng-Hong Zheng Yong-Tang Huang Hao Sun Han-Dong |
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| Institution: | State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China. |
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| Abstract: | Phytochemical investigation of the stems of Kadsura heteroclita led to isolation of 16 compounds, including the triterpenoid named longipedlactone J (2), and two dibenzocyclooctadiene type lignans named heteroclitin I and J (3, 4). Compounds 8-10, 14, and 15 were weakly active as anti-HIV agents, whereas compounds 6 and 12 exhibited moderate anti-HIV activity with EC50 values of 1.6 microg/mL, and 1.4 microg/mL, therapeutic index (TI) values of 52.9, and 65.9, respectively. Their structures were established by spectroscopic methods, including application of 2D NMR techniques and CD spectra. |
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| Keywords: | Kadsura heteroclita Schisandraceae Triterpenoid Dibenzocyclooctadiene type lignans Anti-HIV-1 activity |
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