The surface morphology of normal and malignant rat liver epithelial cells in culture |
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Authors: | T D Allen P T Iype Martin J Murphy |
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Institution: | (1) Paterson Laboratories, Christie Hospital and Holt Radium Institute, M20 9BX Withington, Manchester, England;(2) Laboratories for Developmental Hematopoiesis, Sloan-Kettering Institute for Cancer Research, 410 East 68th Street, 10021 New York, New York |
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Abstract: | Summary A direct comparison has been made between normal parenchymal cells cultured from rat liver and malignant cells from both a
rat liver tumor and a spontaneously transformed line derived from the parent rat culture. In all nondividing cells there was
a 3- to 5-fold increase in the population of surface microvilli on the malignant cells compared to the normal cells. Notable
variations in overall morphology were also observed when cells were incubated in arginine-deficient medium.
During the course of this work T. D. Allen and P. T. Iype were supported by grants from the Medical Research Council and Cancer
Research Campaign, and M. J. Murphy, Jr. was supported by a Special Fellowship of the Leukemia Society of America, Inc. and
the Jean Shaland Fund. |
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Keywords: | liver in vitro malignant surface morphology |
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