Vervet monkey (Cercopithecus aethiops sabaeus) whole blood serotonin level is determined by platelet uptake sites |
| |
| Authors: | G L Brammer M T McGuire M J Raleigh |
| |
| Affiliation: | 1. Nonhuman Primate Laboratory, Sepulveda Veterans Administration Medical Center, Sepulveda, CA. 91343, USA;3. Department of Psychiatry and Biobehavioral Sciences, School of Medicine, University of California at Los Angeles, Los Angeles, CA. 90024, USA;1. Post Graduate Teaching Department of Chemistry, Rashtrasant Tukdoji Maharaj Nagpur University, Nagpur-440033, India;2. Post Graduate Department of Chemistry, Seth Kesarimal Porwal College of Arts, Science and Commerce, Kamptee-441001, India;3. Research and Development Division, Apple Chemie India Private Limited, Nagpur-441108, India;4. Post Graduate Department of Microbiology, Seth Kesarimal Porwal College of Arts, Science and Commerce, Kamptee-441001, India;1. Research Institute for the Environment and Livelihoods, Charles Darwin University, Darwin, NT 0909, Australia;2. Neo Synthesis Research Centre, Polgasowita, Sri Lanka;3. National Manager, Performance & Innovation, Plant Health Australia Level 1, 1 Phipps Close, Deakin ACT 2600, Australia;1. Ph.D.’s Degree Program in Biology (International Program), Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand;2. Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand;3. Postharvest Technology Innovation Center, Ministry of Higher Education, Science, Research and Innovation, Bangkok, 10400, Thailand;4. Research Center in Bioresources for Agriculture, Industry and Medicine, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand;1. Department of Chemistry, Guru Nanak Khalsa College, Nathalal Parekh Marg, Matunga, Mumbai 400019, India;2. Department of Polymer and Surface Engineering, Institute of Chemical Technology, Nathalal Parekh Marg, Matunga, Mumbai 400019, India;3. KLE College of Science and Commerce, Plot No. 29, Sector-01, Kalamboli, Navi Mumbai 410218, India |
| |
| Abstract: | Whole blood serotonin levels in adult male vervet monkeys living in social groups are sensitive to the animals' social environment. The mechanisms that translate different behavioral and environmental cues into altered whole blood serotonin levels are unknown. In this study, we have measured platelet number, size, serotonin content, and serotonin uptake, as well as the serum concentrations of tryptophan, Mg+2 and Ca+2. Results showed that whole blood serotonin levels, platelet serotonin content, and the serotonin uptake parameter Vmax were stable within animals on repeated sampling. The whole blood serotonin level was highly positively associated with platelet serotonin content, and the platelet serotonin content was highly positively associated with Vmax. These findings suggested that whole blood serotonin levels were a function of the number of platelet uptake sites. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
