Metabolism of hygrine in Atropa,Hyoscyamus and Physalis |
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Authors: | Brian A. McGaw Jack G. Woolley |
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Affiliation: | School of Pharmacy, Leicester Polytechnic, Leicester LEI 9BH, U.K. |
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Abstract: | Three-month-old plants of Physalis alkekengi, Atropa belladonna and Hyoscyamus niger were fed via the roots with either d( + ) or l( - )-hygrine-[2′- 14C]. The feeding experiments were terminated after 7 days when the following alkaloids were isolated from the paired groups of plants: tigloidine, 3α-tigloyloxytropane and cuscohygrine from Physalis; hyoscyamine from Hyoscyamus and from Atropa. In contrast to Datura these genera appear to use both hygrine enantiomers in the biosynthesis of the tropane ring. |
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Keywords: | Solanaceae biosynthesis tropane alkaloids cuscohygrine |
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