Circadian Cycle-Dependent MeCP2 and Brain Chromatin Changes |
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| Authors: | Alexia Martínez de Paz Jose Vicente Sanchez-Mut Mireia Samitier-Martí Paolo Petazzi Mauricio Sáez Karolina Szczesna Dori Huertas Manel Esteller Juan Ausió |
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| Institution: | 1. Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain.; 2. Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain.; 3. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain.; 4. Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada.; University of Insubria, ITALY, |
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| Abstract: | Methyl CpG binding protein 2 (MeCP2) is a chromosomal protein of the brain, very abundant especially in neurons, where it plays an important role in the regulation of gene expression. Hence it has the potential to be affected by the mammalian circadian cycle. We performed expression analyses of mice brain frontal cortices obtained at different time points and we found that the levels of MeCP2 are altered circadianly, affecting overall organization of brain chromatin and resulting in a circadian-dependent regulation of well-stablished MeCP2 target genes. Furthermore, this data suggests that alterations of MeCP2 can be responsible for the sleeping disorders arising from pathological stages, such as in autism and Rett syndrome. |
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