BTNL2 Gene Polymorphism and Sarcoidosis Susceptibility: A Meta-Analysis |
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| Authors: | Yihua Lin Jia Wei Lili Fan Deyun Cheng |
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| Institution: | 1. Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.; 2. Department of Respiratory Medicine, the First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.; University of Birmingham, UNITED KINGDOM, |
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| Abstract: | BackgroundButyrophilin-like 2 (BTNL2) rs2076530 gene polymorphism has been implicated in susceptibility to sarcoidosis. However, results from previous studies are not consistent. To assess the association of BTNL2 polymorphism and sarcoidosis susceptibility, a meta-analysis was performed.MethodsPubMed, Embase were searched for eligible case-control studies. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated.ResultsTen studies involving a total of 3303 cases and 2514 controls were included in this meta-analysis. Combined data indicated that BTNL2 rs2076530 polymorphism was associated with sarcoidosis susceptibility in allelic model (A vs. G, OR = 1.59, 95%CI: 1.47–1.72), dominant model (AA + AG vs. GG, OR = 2.10, 95%CI: 1.67–2.65), and recessive model (AA vs. AG + GG, OR = 1.93, 95%CI: 1.49–2.50).ConclusionsThis meta-analysis indicates that BTNL2 rs2076530 polymorphism contributes to the risk of sarcoidosis. |
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