Increased Brain Levels of Platelet-Activating Factor in a Murine Acquired Immune Deficiency Syndrome Are NMDA Receptor-Mediated |
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| Authors: | Keiji Nishida S P Markey Yelena Kustova †Herbert C Morse III Phil Skolnick Anthony S Basile Yoshitatsu Sei |
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| Institution: | Section on Analytical Biochemistry, Laboratory of Clinical Science, National Institute of Mental Health;; Laboratory of Neuroscience, National Institute of Diabetes, Digestive and Kidney Diseases;and; Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A. |
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| Abstract: | Abstract: Mice infected with the LP-BM5 murine leukemia virus (MuLV) develop an immunodeficiency syndrome (murine AIDS) and an encephalopathy characterized by impaired spatial learning and memory. Because platelet-activating factor (PAF) has been implicated in the pathogenesis of HIV-associated dementia complex, brain PAF levels were measured in LP-BM5 MuLV-infected mice. PAF levels in cerebral cortex and hippocampus were significantly increased at 6 and 12 weeks after LP-BM5 MuLV inoculation, whereas significant increases in striatal and cerebellar PAF levels were observed only at 12 weeks after inoculation. Administration of the NMDA antagonist MK-801 significantly reduced the increased PAF levels in the cerebral cortex and hippocampus of LP-BM5 MuLV-infected mice. These results indicate that the LP-BM5 MuLV-induced increases in brain PAF levels are the result of NMDA receptor activation and are consistent with the hypothesis that elevated CNS PAF levels contribute to the behavioral deficits observed in LP-BM5 MuLV-infected mice. |
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| Keywords: | AIDS LP-BM5 murine leukemia virus Brain Encephalopathy Platelet-activating factor |
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