Triterpenoids from Tripterygium wilfordii |
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| Authors: | Duan H Takaishi Y Momota H Ohmoto Y Taki T Jia Y Li D |
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| Institution: | Faculty of Pharmaceutical Sciences, University of Tokushima, Japan. |
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| Abstract: | The extract (T(II)) of Tripterygium wilfordii Hook f. afforded four triterpenoids: wilforic acid D (3beta,24-epoxy-2alpha-hydroxy-24R*-ethoxy-29-friedelanoic acid); (E) 3beta,24-epoxy-2-oxo-3alpha-hydroxy-29-friedelanoic acid; (F) 2beta-hydroxy-3-oxo-friedelan-29-oic acid; 29-hydroxy-3-oxo-olean-12-en-28-oic acid and 17 known triterpenoids. Their structures were established on the basis of spectroscopic studies. In a bioactivity analysis, only the known dulcioic acid compound showed a significant inhibitory effect on cytokine production. |
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