Self-annealing of 4 S strands from replicating simian virus 40 DNA |
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| Authors: | G C Fareed G Khoury N P Salzman |
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| Affiliation: | Laboratory of Biology of Viruses National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda, Md 20014, U.S.A. |
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| Abstract: | The nascent short strands (4 S) isolated from replicating Simian, virus 40 DNA hybridize specifically with denatured SV40 DNA and self-anneal extensively (70 to 92%) when incubated at 68 °C in 1 m-NaCl. Since complementary genetic sequences are present in the 4 S strands, both growing chains of SV40 DNA appear to be synthesized discontinuously at each replication fork. |
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