A new turn in Rho GTPase activation by Escherichia coli cytotoxic necrotizing factors |
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| Authors: | Aktories Klaus Schmidt Gudula |
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| Affiliation: | 11. Biology PhD Program, Stanford University, Stanford, CA 94305, USA;1. Department of Earth and Planetary Sciences, University of California Davis, One Shields Ave., Davis, CA 95616, USA;2. State Key Laboratory of Lithospheric Evolution, Institute of Geology and Geophysics, Chinese Academy of Sciences, P. O. Box 9825, Beijing 100029, China;3. Key Laboratory of Cenozoic Geology and Environment, Institute of Geology and Geophysics, Chinese Academy of Sciences, P. O. Box 9825, Beijing 100029, China |
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| Abstract: | Various bacterial protein toxins and effectors target Rho GTPases, which are eukaryotic regulators of signal transduction pathways. Many toxins inactivate these GTPases but some, such as the cytotoxic necrotizing factors (CNFs) from Escherichia coli, activate them by deamidation. Recent studies have provided exciting new clues to the functional consequences of the activation of Rho GTPases by CNFs and its effect on the host-pathogen interaction. |
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