高脂血症合并高血压患者临床特征及疾病严重程度的危险因素分析

摘要 目的：分析高脂血症合并高血压患者临床特征及疾病严重程度的危险因素。方法：回顾性分析2021年12月-2022年12月我院收治的高血压和高脂症患者共532例，依据其血压和血脂水平分为高血脂组（n=240）和高血脂合并高血压组（n=292）。比较两组临床资料，采用二分类Logistic回归分析影响高脂血症合并高血压患者病情严重程度的独立危险因素。结果：高血脂合并高血压组的吸烟史、家族史、患有糖尿病史、高血脂病史一年以上人数占比及血清甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、血尿酸（UA）、C反应蛋白（CRP）水平均与高血脂组有差异（P<0.05）。高血脂合并高血压重度组有吸烟史、家族史、患有糖尿病、高血压病及血清UA、CRP水平均高于中度组（P<0.05）。二分类Logistic回归分析结果显示，有吸烟史、家族史、患有糖尿病、高血压病及血清UA、CRP水平升高是影响高脂血症合并高血压患者病情严重程度的独立危险因素（P<0.05）。结论：吸烟史、家族史、患有糖尿病、高血压病，UA含量以及CRP水平升高是影响高脂血症合并高血压患者病情严重程度的独立危险因素，可作为临床提示高脂血症合并高血压病情发展的指标。

Analysis of Risk Factors for Clinical Characteristics and Disease Severity in Patients with Hyperlipidemia Combined with Hypertension

ABSTRACT Objective: To analyze the risk factors for clinical characteristics and disease severity in patients with hyperlipidemia combined with hypertension. Methods: A total of 532 patients with hypertension and hyperlipidemia admitted to our hospital from December 2021 to December 2022 were retrospectively analyzed and divided into the hyperlipidemia group (n=240) and the hyperlipidemia combined with hypertension group (n=292) based on their blood pressure and lipid levels. The independent risk factors affecting the severity of disease in patients with hyperlipidemia combined with hypertension were analyzed by binary classification logistic regression. Results: Smoking history of hyperlipidemia with hypertension, family history, history of diabetes, hyperlipidemia history and serum triglycerides (TG), total cholesterol (TC), low density lipoprotein (LDL), high-density lipoprotein (HDL), blood uric acid (UA), C reactive protein (CRP) levels were different from the high lipid group (P<0.05). In the severe hyperlipidemia combined with hypertension group, the levels of smoking history, family history, having diabetes, hypertension and serum UA and CRP were higher than those in the moderate group (P<0.05). Binary classification logistic regression analysis showed that a history of smoking, family history, having diabetes, hypertension and elevated serum UA and CRP levels were independent risk factors for the severity of the disease in patients with hyperlipidemia combined with hypertension (P<0.05). Conclusion: History of smoking, family history, diabetes mellitus, hypertension, elevated UA levels and CRP levels are independent risk factors for the severity of hyperlipidemia combined with hypertension and can be used as clinical indicators for the progression of hyperlipidemia combined with hypertension.