中晚期肝癌患者采用超声介入治疗引发并发症影响因素分析

摘要 目的：分析中晚期肝癌患者采用超声介入治疗引发并发症影响因素。方法：选取2019年2月～2023年2月在本院接受超声介入治疗的120例中晚期肝癌患者进行研究，治疗后记录患者的并发症发生率，并根据并发症发生情况将患者分为有并发症组（36例）和无并发症组（84例），分别对两组患者的一般特征{性别、年龄、有无基础疾病、TNM分期、Child-Pugh分级、形态分型、肿瘤体积、腹水、门静脉高压、血供情况、白蛋白（ALB）及血清学指标[血红蛋白（Hb）、血小板（PLT）、凝血酶原时间（PT）、总胆红素（TBIL）、谷丙转氨酶（ALT）、谷草转氨酶（AST）]}进行分析，并建立logistic模型，对一般特征在中晚期肝癌患者超声介入治疗后引发并发症的影响中进行单因素和多因素分析。结果：120例患者经超声介入治疗后的并发症发生率为30.00%。有并发症组Child-Pugh B级、腹水+、ALB＜30 g/L的患者明显高于无并发症组，差异有统计学意义（P＜0.05）。单因素分析结果显示，Child-Pugh分级、腹水、ALB是导致中晚期肝癌患者超声介入治疗后引发并发症的影响因素（P＜0.05）。多因素logistic分析结果显示，Child-Pugh B级、腹水、ALB＜30 g/L均是导致中晚期肝癌患者超声介入治疗后引发并发症的独立危险因素（P＜0.05）。结论：Child-Pugh分级、腹水和ALB均是导致中晚期肝癌患者超声介入治疗后引发并发症的独立因素，只有尽早针对该类影响因素加强防治干预，才能有效降低中晚期患者的并发症发生率。

Analysis of Influencing Factors of Complications Caused by Ultrasound Interventional Therapy in Patients with Advanced Liver Cancer

ABSTRACT Objective: To analyze the influencing factors of complications caused by ultrasound interventional therapy in patients with advanced liver cancer. Methods: A total of 120 patients with advanced liver cancer who underwent ultrasound interventional therapy in our hospital from February 2019 to February 2023 were selected for the study. The incidence of complications was recorded after treatment, and the patients were divided into complication group (36 cases ) and non-complication group (84 cases ) according to the occurrence of complications. The general characteristics of the two groups of patients { gender, age, presence or absence of underlying diseases, TNM stage, Child-Pugh classification, morphological classification, tumor volume, ascites, portal hypertension, blood supply, albumin (ALB) and serological indicators [ hemoglobin (Hb), platelet (PLT), prothrombin time (PT), total bilirubin (TBIL), alanine aminotransferase (ALT), aspartate aminotransferase (AST) ] were analyzed, and a logistic model was established. Univariate and multivariate analyses were performed on the effects of general characteristics on complications after ultrasound interventional therapy in patients with advanced liver cancer. Results: The incidence of complications in 120 patients after ultrasound intervention was 30.00%. The patients with Child-Pugh B grade, ascites + and ALB < 30 g/L in the complication group were higher than those in the non-complication group (P<0.05). The results of univariate analysis showed that Child-Pugh classification, ascites and ALB were the influencing factors of complications after ultrasound interventional therapy in patients with advanced liver cancer (P<0.05). Multivariate logistic analysis showed that Child-Pugh B grade, ascites, and ALB < 30 g/L were all independent risk factors for complications after ultrasound interventional therapy in patients with advanced liver cancer (P<0.05). Conclusion: Child-Pugh classification, ascites and ALB are all independent factors leading to complications after ultrasound interventional therapy in patients with advanced liver cancer. Only by strengthening prevention and treatment intervention for such influencing factors as soon as possible can we effectively reduce the incidence of complications in patients with advanced liver cancer.