Synthesis of novel 5-substituted indirubins as protein kinases inhibitors |
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| Authors: | Beauchard Anne Ferandin Yoan Frère Stéphane Lozach Olivier Blairvacq Mélina Meijer Laurent Thiéry Valérie Besson Thierry |
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| Institution: | Laboratoire de Biotechnologies et de Chimie Bio-organique, FRE CNRS 2766, UFR Sciences Fondamentales et Sciences pour l'Ingénieur, Université de La Rochelle, Batiment Marie Curie, 17042 La Rochelle, France. |
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| Abstract: | In an effort to identify new pharmacological inhibitors of disease-relevant protein kinases with increased potency and selectivity, we synthesized and evaluated new 5-substituted indirubins. The effects of 34 indirubin derivatives on CDK1/cyclin B, CDK5/p25, and GSK-3, as well as on SH-SY5Y human neuroblastoma cell survival, were investigated. |
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