The human amiloride-sensitive Na+/H+ antiporter: localization to chromosome 1 by in situ hybridization |
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| Authors: | M G Mattei C Sardet A Franchi J Pouysségur |
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| Affiliation: | INSERM U242, Centre de Génétique Médicale, H?pital d'enfants de la Timone, Marseille, France. |
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| Abstract: | The Na+/H+ antiporter is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells. We cloned the human gene capable of complementing antiporter-deficient mouse fibroblasts and isolated an exon-containing genomic DNA fragment. Using this genomic probe, we mapped the putative structural gene of the amiloride-sensitive Na+/H+ antiporter to the human chromosome region 1p35----p36.1 by in situ hybridization. |
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