一种快速和优质的蛋白质结构刚体叠加方法

统计了１１０族同源蛋白质的多重结构联配结果，得到了局部环境依赖的氨基酸相似分数表。按此表可实施快速和优质的蛋白质结构刚性叠加，用于蛋白质工程。跟目前最好的遗传算法比较，此法可达到相同的品质（尽可能多的拓扑等价残基对和尽可能小的均方根距离），但ＣＰＵ时间降了１个到２个数量级，对大蛋白更为明显。

A RAPID AND QUALITY METHOD OF PROTEIN RIGID-BODY SUPERPOSITION

An enact mnent-dependent alnino ads similarity table was obtained from the statistica ofthe alignment database of 110 families of protein structrm. Rapid and quality rigid-bodysupoposition of protein structare for protein eqineethe was achieved aimlding tO the table.Compacts with the hot genetic algorithm of the known, our approach nduas the calculatingthe by one to tWo magnifications, while keeping sallar quality (nUmber of topologicalquivalent nsidues and smaller r.m.s.d.).