心肺复苏后脑缺血再灌注损伤治疗理念及相关动物模型研究进展

心肺复苏后脑缺血再灌注损伤是一个复杂的病理生理变化过程,由多种损伤机制共同参与。自心肺复苏后系统性综合治疗和亚低温治疗在临床上广泛应用后,目前已有多种治疗理念在不同的动物实验和动物模型基础上被提出,包括缺血预处理、药物预处理、缺血后处理、和药物后处理,而后吸入麻醉药对心肺复苏后脑缺血再灌注损伤的保护作用受到了人们的重视,而七氟烷后处理已经成为目前研究的热点之一。为了指导临床上的心肺复苏,人们一直在利用不同动物模型,探究不同保护方法,寻找有效的脑保护药物。而各种治疗理念的提出均是建立在动物实验和动物模型的基础上,窒息性心肺复苏模型模拟围术期气道梗阻,能较贴切的复制临床上由窒息引起的心肺复苏后脑损伤,对将来指导临床复苏具有重大意义。

Treatment Concept of Cerebral Ischemia/Reperfusion Injury after Cardiopulmonary Resuscitation and the Research of Relevant Animal Models

Cerebral ischemia/ reperfusion injury after cardiopulmonary resuscitation is a complex pathophysiological process, with a variety of damage mechanisms involved.A variety of treatment concept were put forward on the basis of different animals and animal models. Since the systemic comprehensive treatment and the hypothermia treatment after cardiopulmonary resuscitation (CPR) are widely used in clinic, there are many kinds of treatments based on different animals and animal models have been proposed, including ischemic preconditioning, drugs preconditioning, ischemic postconditioning, and drugs postconditioning. Then inhaled anesthetics'' protection on brain ischemia reperfusion injury after cardiopulmonary resuscitation (CPR) has been paid widely attention, and sevoflurane postconditioning has become one of the hot spot of current research. In order to guide cardiopulmonary resuscitation (CPR) in the clinic, people have been using various animal models, exploring different protection methods and searching for effective cerebral protection drugs. And no idea was put forward without accompany by numerous animal trails and models, so different animal models establishment have to offer. Asphyxial Cardiac Arrest model, simulating perioperative airway obstruction, copying cerebral injury after cardiopulmonary resuscitation (CPR) in the clinical, will have more practical significance in guiding the clinical recovery.