The influence of some sympatholytic,parasympatholytic and serotonin-synthesis-inhibiting agents on the ultrastructure of the rabbit pineal organ |
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| Authors: | Dr. H. J. Romijn |
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| Affiliation: | (1) Department of Electron Microscopy, Netherlands Central Institute for Brain Research, Amsterdam, The Netherlands;(2) Netherlands Central Institute for Brain Research, Ijdijk 28, Amsterdam, The Netherlands |
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| Abstract: | The influence of certain drugs on the ultrastructure of rabbit pinealocytes was studied. The results obtained after administration of p-chlorophenylalanine and p-chloroamphetamine support the hypothesis proposed earlier that the smooth endoplasmic reticulum in the light pinealocytes is involved in indoleamine synthesis. The administration of either one of the sympatholytic agents, 6-hydroxydopamine or alpha-methyl-p-tyrosine, induced typical fine structural changes corresponding to those observed after surgical sympathectomy. |
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| Keywords: | Pineal organ Rabbit Drugs Ultrastructure |
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