DNA indels in coding regions reveal selective constraints on protein evolution in the human lineage |
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| Authors: | Nicole de la Chaux Philipp W Messer Peter F Arndt |
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| Institution: | 1.Department for Computational Molecular Biology,Max-Planck-Institute for Molecular Genetics,Berlin,Germany;2.Department for Biochemistry,University of Zurich,Zürich,Switzerland |
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| Abstract: | Background Insertions and deletions of DNA segments (indels) are together with substitutions the major mutational processes that generate
genetic variation. Here we focus on recent DNA insertions and deletions in protein coding regions of the human genome to investigate
selective constraints on indels in protein evolution. |
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