Ebulitins: A new family of type 1 ribosome-inactivating proteins (rRNA N-glycosidases) from leaves of Sambucus ebulus L. that coexist with the type 2 ribosome-inactivating protein ebulin 1 |
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Authors: | Fernando M. de Benito, Lucí a Citores, Rosario Iglesias, J. Miguel Ferreras, Fernando Soriano, Javier Arias, Enrique M ndez,Tom s Girb s |
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Affiliation: | Fernando M. de Benito, Lucía Citores, Rosario Iglesias, J. Miguel Ferreras, Fernando Soriano, Javier Arias, Enrique Méndez,Tomás Girbés, |
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Abstract: | A new family of single chain (type 1) ribosome-inactivating proteins (RIPs), that we have named ebulitins, have been found in mature leaves of Sambucus ebulus L., a caprifoliaceae plant also known to contain a non-toxic two chain (type 2) RIP named ebulin 1 in its leaves. Ebulitins are basic proteins of Mr 32,000, 29,000 and 29,000 for ebulitins , β and γ, respectively. The simultaneous presence of different basic type 1 and acidic type 2 RIPs in the same plant and in the same tissue is described here for the first time and opens a new door in research into RIPs. |
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Keywords: | Ribosome-inactivating protein rRNAN-glycosidase Protein synthesis inhibition Ebulitin Ebulin 1 Sambucus ebulus L. |
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