幽门螺杆菌在牙菌斑及胃粘膜分布研究

目的:探讨幽门螺杆菌(Helicobacter pylori,Hp)在牙菌斑及胃粘膜分布状况。方法:采用聚合酶链式反应(polym erase chain reaction,PCR)技术对80 例慢性胃溃疡患者的牙菌斑及胃粘膜组织进行Hp 检测。结果:48 例胃粘膜Hp 阳性的患者中12 例牙菌斑Hp 阳性;胃粘膜Hp 阴性的患者无一例牙菌斑Hp 阳性;胃Hp 阳性检出率大于牙菌斑。结论:幽门螺杆菌不仅存在于胃粘膜组织中,也存在于口腔牙周组织中。提示牙菌斑可能是Hp 的重要寄居地。

DISTRIBUTION OF HELICOBACTER PYLORI BETWEEN STOMACHAL

Objective: Our objective was to investigate the distribution of Helicobacter pylori between stomachal mucosa and dental plaque.Methods: Stomachal mucosa and dental plaques in eighty patients with chronic gastric ulcer were analysed by polymerase chain reaction.Results: The examination of stomachal mucosa revealed that 48 cases had H.pylori and 32 cases did not have.Twelve patients with proven H.pylori postitive in gastric ulcer portion were also identified in their rental plaques.None of patients without H.pylori gastric ulcer had H.pylori in their dental plaques.The recovery rate of H.pylori in dental plaques was much lower than that in stomachal mucosa (p<0 01).Conclusions:H.pylori could be found indental plaques and stomachal mucosa.The detection of H.pylori in dental plaques suggested that the dental plaque is a possible sanctuary for H.pylori.