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Ageing is associated with a decline in peripheral blood CD56bright NK cells |
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| Authors: | Shivani M Chidrawar Naeem Khan Y L Tracey Chan Laxman Nayak Paul AH Moss |
| Affiliation: | (1) Medical School, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK;(2) Institute of Cancer Studies, Vincent Drive, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK;(3) Centre for Applied Gerontology, Selly Oak Hospital, Raddlebarn Road, Birmingham, B29 6JD, UK |
| Abstract: | BackgroundNatural killer (NK) cells are cytotoxic lymphocytes that lack CD3 and express variable levels of CD16, CD56 and CD57. In recent years NK cells have been categorised into two major groups based on the level of CD56 expression. This phenotypic classification correlates with functional activity as CD56bright NK cells are the major cytokine producing subset whereas CD56dim NK cells exhibit greater cytotoxic activity. Previous studies have revealed a reduction in total NK cell numbers in association with ageing and this study sought to determine the potential influence of ageing on the number of NK cell subsets within peripheral blood. |
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