Streptozotocin-induced diabetes in the rat is associated with changes in vaginal hemodynamics, morphology and biochemical markers |
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| Authors: | Noel N Kim Miljan Stankovic Tulay T Cushman Irwin Goldstein Ricardo Munarriz Abdulmaged M Traish |
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| Institution: | (1) Institute for Sexual Medicine, Department of Urology, Boston University School of Medicine, Boston, USA;(2) Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, USA;(3) Department of Biochemistry, Boston University School of Medicine, Boston, USA |
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| Abstract: | Background Diabetes is associated with declining sexual function in women. However, the effects of diabetes on genital tissue structure,
innervation and function remains poorly characterized. In control and streptozotocin-treated female rats, we investigated
the effects of diabetes on vaginal blood flow, tissue morphology, and expression of arginase I, endothelial nitric oxide synthase
(eNOS) and cGMP-dependent protein kinase (PKG), key enzymes that regulate smooth muscle relaxation. We further related these
changes with estrogen receptor alpha (ERα) and androgen receptor (AR) expression. |
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