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Analysis of circular genome rearrangement by fusions, fissions and block-interchanges
Authors:Chin Lung Lu  Yen Lin Huang  Tsui Ching Wang  Hsien-Tai Chiu
Institution:(1) Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, 300, ROC, Taiwan;(2) Department of Computer Science, National Tsing Hua University, Hsinchu, 300, ROC, Taiwan
Abstract:

Background  

Analysis of genomes evolving via block-interchange events leads to a combinatorial problem of sorting by block-interchanges, which has been studied recently to evaluate the evolutionary relationship in distance between two biological species since block-interchange can be considered as a generalization of transposition. However, for genomes consisting of multiple chromosomes, their evolutionary history should also include events of chromosome fusions and fissions, where fusion merges two chromosomes into one and fission splits a chromosome into two.
Keywords:
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