Characterization of the family of Mistic homologues |
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Authors: | Tarmo P Roosild Mark Vega Samantha Castronovo Senyon Choe |
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Institution: | (1) Structural Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA |
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Abstract: | Background Mistic is a unique Bacillus subtilis protein with virtually no detectable homologues in GenBank, which appears to integrate into the bacterial membrane despite
an overall hydrophilic composition. These unusual properties have been shown to be useful for high-yield recombinant expression
of other membrane proteins through fusion to the C-terminus of Mistic. To better understand the structure and function of
Mistic, we systematically searched for and characterized homologous proteins among closely related bacteria. |
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