Dissecting the coupling between the voltage sensor and pore domains |
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| Authors: | Roux Benoit |
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| Affiliation: | Institute for Molecular Pediatric Sciences and Department of Biochemistry and Molecular Biology, University of Chicago, Gordon Center for Integrative Sciences, 929 East 57th Street, Chicago, Ilinois 60637, USA. |
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| Abstract: | The gating mechanism of K(v) channels is not known. In this issue of Neuron, Soler-Llavina et al. present fascinating results that support the concept of relatively independent voltage-sensing modules. However, they also find that its interactions with the pore domain are rather complex, with specific S4-S5 intersubunit contacts underlying the concerted transition leading to the channel opening. |
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