p63 Immunoexpression in lip carcinogenesis |
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Authors: | Flávia Caló Aquino Xavier Christina Maeda Takiya Sílvia Regina Almeida Reis Luciana Maria Pedreira Ramalho |
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Institution: | 1.Integrated Clinic and Propedeutics Department, School of Dentistry,Federal University of Bahia,Canela, Salvador,Brazil;2.Department of Histology and Embryology, Institute of Biomedical Sciences,Federal University of Rio de Janeiro,Rio de Janeiro,Brazil;3.Praia do Castelo,S?o Paulo,Brazil |
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Abstract: | Actinic cheilitis (AC) is a potentially malignant disorder, which can present degrees of epithelial dysplasia, and may even
evolve into lip squamous cell carcinoma (LSCC). Since p63 is a protein homologous to p53, which can be associated with tumorigenesis
in epithelial tissues, this study aims to evaluate it in AC and LSCC, in the hopes to estimate the biological behavior of
these lesions. Forty AC lesions and sixty-five cases of LSCC were quantitatively analyzed by immunohistochemistry, using anti-p63
antibody with ten cases of normal lip mucosa used as a control group. In all AC and LSCC cases studied, it was possible to
detect the presence of the p63 protein. There was no statistically significant difference between immunostained cells and
degree of epithelial dysplasias, nor between the LSCC grading malignancy. Nevertheless, p63 immunoexpression showed to be
significantly correlated with AC and LSCC lesions as compared to normal lip epithelium. The results indicate that p63 protein
is consistently expressed in AC and LSCC, and might be of help in the differential diagnosis between normal and dysplastic/neoplastic
epithelium, although the evaluation using a primary antibody to all isotypes did not prove to be a risk biomarker during lip
carcinogenesis. Thus, the production of antibodies for the six different p63 isotypes is urged, since in isolation they can
have predictive value, mainly the ΔNp63 isoforms. |
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Keywords: | Actinic cheilitis Squamous cell carcinoma Lip neoplasms Tumor biological markers Immunohistochemistry |
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