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Non-lethal Candida albicans cph1/cph1 efg1/efg1 mutant partially protects mice from systemic infections by lethal wild-type cells |
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| Authors: | Yun-Liang Yang Chiung-Tong Chen Chin-Fu Hsiao |
| Institution: | a Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan, ROC b Division of Clinical Research, National Health Research Institutes, Miaoli, Taiwan, ROC c Division of Biotechnology & Pharmaceutical Research, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County, 350, Taiwan, ROC d Division of Biostatistics and Bioinformatics, National Health Research Institutes, Miaoli, Taiwan, ROC |
| Abstract: | Although Candida albicans cph1/cph1 efg1/efg1 mutant cells are not lethal to mice, they proliferated in infected mice instead of simply being cleared by the host immune system. Here, we have shown that the cph1/cph1 efg1/efg1 mutant partially protects mice from systemic infections by the lethal wild-type Candida albicans cells. Our results further indicate that a second dose of the cph1/cph1 efg1/efg1 mutant did not boost the degree of protection. |
| Keywords: | Candida albicans Mouse model Protection Virulence |
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