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Role of the synaptic microenvironment in functional modification of synaptic transmission |
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| Authors: | D A Rusakov Ming-Yuan Min G G Skibo L P Savchenko M G Stewart D M Kullmann |
| Institution: | (1) National Institute for Medical Research, London, UK;(2) Institute of Neurology, London, UK;(3) Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine;(4) Dnepropetrovsk State University, Dnepropetrovsk, Ukraine;(5) The Open University, Milton Keynes, UK |
| Abstract: | Experiments on hippocampal slices showed that perfusion with a dextran solution more effectively facilitates AMPA-mediated transmission in structurally complex synapses of mossy fibers of Shaffer collaterals. Estimates for changes in the extracellular Ca2+ concentration in the close vicinity of a reconstructed synapse during the action potential development are obtained. The results together with data about the rather small (0.5 μm) characteristics distance between neighboring synapses showed that the probability of mutual intersynaptic influence via the microenvironment is high. A probable functional role of such influences is discussed. |
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