A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice |
| |
Authors: | Wakimoto Koji Chiba Hiroaki Michibata Hideo Seishima Mariko Kawasaki Satoshi Okubo Kousaku Mitsui Hiroshi Torii Hideshi Imai Yuji |
| |
Institution: | Discovery Research Laboratory, Advanced Medical Research Department, Tanabe Seiyaku Co., Ltd, 3-16-89 Kashima, Yodogawa-ku, Osaka 532-8505, Japan. wakimoto@tanabe.co.jp |
| |
Abstract: | Psoriasis is a skin disease with epidermal keratinocyte hyperproliferation and altered differentiation. To identify novel psoriasis-related genes, we investigated differentially expressed genes between normal and psoriatic skin. We identified a novel acyl CoA:diacylglycerol acyltransferase 2 (DGAT2) gene, which was decreased in human psoriatic skin. DGAT2 mRNA was expressed in sebaceous glands of normal human skin. DGAT2 protein was detected on endoplasmic reticulum. DGAT2 catalyzes the final step in the production of triglycerides and the accumulation of triglycerides in the tissues is considered to be related to insulin resistance. Therefore, we also investigated the expression of the DGAT2 gene in diabetic mice. DGAT2 mRNA was increased in the adipose, small intestine, and skeletal muscle in diabetic mice. |
| |
Keywords: | DGAT Psoriasis Diabetes Triglyceride |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|