Antiperoxidative and Antiinflammatory Effect of <Emphasis Type="Italic">Sida Cordifolia</Emphasis> Linn. on Quinolinic Acid Induced Neurotoxicity |
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Authors: | S S Swathy Seema Panicker R S Nithya M M Anuja S Rejitha M Indira |
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Institution: | (1) Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram, 695 581 Kerala, India; |
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Abstract: | Sida cordifolia is a plant belonging to the Malvaceae family used in many ayurvedic preparations. This study aimed at assessing the effects
of ethanolic extract of Sida cordifolia root on quinolinic acid (QUIN) induced neurotoxicity and to compare its effect with the standard drug deprenyl in rat brain.
Rats were divided into six groups: (1) control group (2) QUIN (55 μg/100 g bwt/day) (3) 50% ethanolic plant extract treated
group (50 mg/100 g bwt/day) (4) Deprenyl (100 μg/100 g bwt/day) (5) QUIN (55 μg/100 g bwt/day) + 50% ethanolic plant extract
treated group (50 mg/100 g bwt/day) (6) QUIN (55 μg/100 g bwt/day) + Deprenyl (100 μg/100 g bwt/day). At the end of the experimental
period a status of lipid peroxidation products, protein peroxidation product, activities of the scavenging enzymes and the
activities of the inflammatory markers were analyzed. Results revealed that the lipid peroxidation products decreased and
the activities of the scavenging enzymes increased significantly in the brain of the plant extract treated group, deprenyl
treated group and also in the coadminstered groups. The activities of markers of inflammatory responses such as cyclooxygenase
and lipoxygenase were found to be significantly increased in the QUIN treated rats and this was decreased upon the administration
of plant extract and deprenyl. In short, the study revealed that 50% ethanolic extract of Sida cordifolia has got potent antioxidant and antiinflammatory activity and the activity is comparable with the standard drug deprenyl. |
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