Luminal calcium regulation of calcium release from sarcoplasmic reticulum |
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| Authors: | Cecilia Hidalgo Paulina Donoso |
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| Institution: | (1) Departamento de Fisología y Biofíica, Facultad de Medicina, Universidad de Chile, Casilla, 70005 Santiago 7, Chile;(2) Centro de Estudios Científicos de Santiago, Casilla, 6443 Santiago 9, Chile |
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| Abstract: | This article discusses how changes in luminal calcium concentration affect calcium release rates from triad-enriched sarcoplasmic reticulum vesicles, as well as single channel opening probability of the ryanodine receptor/calcium release channels incorporated in bilayers. The possible participation of calsequestrin, or of other luminal proteins of sarcoplasmic reticulum in this regulation is addressed. A comparison with the regulation by luminal calcium of calcium release mediated by the inositol 1,4,5-trisphosphate receptor/calcium channel is presented as well. |
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| Keywords: | Calcium Ca2+-channel inosital phosphate ryanodine sarcoplasmic reticulum |
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