Simulation of intracellular $$\hbox {Ca}^{2+}$$ transients in osteoblasts induced by fluid shear stress and its application |
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Authors: | Junqing Sun Wenjun Xie Liang Shi Liyin Yu Jianbao Zhang |
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Institution: | 1.The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology,Xi’an Jiaotong University,Xi’an,China;2.Institute of Biomedical Engineering,School of Life Science and Technology, Xi’an Jiaotong University,Xi’an,China |
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Abstract: | Intracellular \(\hbox {Ca}^{2+}\) transient induced by fluid shear stress (FSS) plays an important role in mechanical regulation of osteoblasts, but the cellular mechanism remains incompletely understood. Here, we constructed a mathematical model combined with experiments to elucidate it. Our simulated and experimental results showed that it was the delay of membrane potential repolarization to produce the refractory period of FSS-induced intracellular calcium transients in osteoblasts. Moreover, the results also demonstrated that the amplitude of FSS-induced intracellular calcium transient is crucial to the proliferation, while its duration is critical to the differentiation, of osteoblasts. Overall, the present study provides a way to understand the cellular mechanism of intracellular calcium transients in osteoblast induced by FSS and explains some of related physiological events. |
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