首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Preferential alkaline phosphatase isoenzyme induction by sodium butyrate
Authors:Fritz Herz  Murray Halwer
Institution:Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467 U.S.A.
Abstract:SW-620, a continuous cell line derived from a poorly differentiated human colon carcinoma, produces two alkaline phosphatases. Under basal conditions the heat-stable, term-placental is the major isoenzyme and the heat-labile, liver/bone/kidney form represents a minor component. Exposing SW-620 cells to sodium butyrate causes induction of increased levels of activity accompanied by a striking shift in isoenzyme distribution not observed heretofore. The activity increase is accounted for entirely by augmentation of the liver/bone/kidney isoenzyme, with the term-placental form not being affected. Two other known alkaline phosphatase inducers, prednisolone and hyperosmolality, do not influence specific activity and isoenzyme distribution. The preferential induction of the liver/bone/kidney form of alkaline phosphatase in SW-620 cells may reflect a butyrate-elicited expression of a more differentiated state.
Keywords:Alkaline phosphatase isozyme  Sodium butyrate  Enzyme induction  (SW-620 cell)
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号