Helicobacter pylori VacA: a new perspective on an invasive chloride channel |
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| Authors: | Joachim Rassow Michael Meinecke |
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| Institution: | 1. Ruhr-Universität Bochum, Institut für Physiologische Chemie, Universitätsstrasse 150, D-44780 Bochum, Germany;2. Georg-August-Universität Göttingen, Abteilung Biochemie II, Humboldtallee 23, D-37073 Göttingen, Germany;3. European Neuroscience Institute Göttingen, D-37077 Göttingen, Germany;1. Department of Gastroenterology, CHLN – Hospital de Santa Maria, Portugal;2. Department of Pathology, CHLN – Hospital de Santa Maria, Portugal |
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| Abstract: | The vacuolating cytotoxin VacA, a polypeptide of about 88 kDa, is one of the major virulence factors of Helicobacter pylori. VacA essentially acts as an invasive chloride channel targeting mitochondria. The results of recent studies open a new perspective on the mechanisms by which VacA causes loss of the mitochondrial membrane potential, mitochondrial fragmentation, formation of reactive oxygen species, autophagy, cell death and gastric cancer. |
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