Chemoenzymatic deacylation of ramoplanin |
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| Authors: | Raffaella Gandolfi Flavia Marinelli Enzio Ragg Diego Romano Francesco Molinari |
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| Institution: | Dipartimento di Scienze Farmaceutiche, Via Venezian 21, 20133 Milano, Italy. |
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| Abstract: | The chemoenzymatic deacylation of ramoplanin A2 is described for the first time: ramoplanin A2 was Boc-protected and hydrogenated to Boc-protected tetrahydroramoplanin, which was subsequently deacylated using an acylase from Actinoplanes utahensis NRRL 12052. The chemoenzymatic process proceeded with 80% overall yield, which favourably compares with the previously described chemical deacylation. |
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