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New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms |
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| Authors: | Paula F Carneiro Samara B do Nascimento Antonio V Pinto Maria do Carmo F R Pinto Guilherme C Lechuga Dilvani O Santos Helvécio M Dos Santos Júnior Jackson A L C Resende Saulo C Bourguignon Vitor F Ferreira |
| Institution: | Universidade Federal do Rio de Janeiro, Núcleo de Pesquisas de Produtos Naturais, 21944-970 Cidade Universitária, RJ, Brazil. |
| Abstract: | New oxirane derivatives were synthesized using six naphthoquinones as the starting materials. Our biological results showed that these oxiranes acted as trypanocidal agents against Trypanosoma cruzi with minimal cytotoxicity in the VERO cell line compared to naphthoquinones. In particular, oxirane derivative 14 showed low cytotoxicity in a mammalian cell line and exhibited better activity against epimastigote forms of T.cruzi than the current drug used to treat Chagas disease, benznidazole. |
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