The capacity of murine alveolar macrophages to stimulate antigen-dependent T-lymphocyte activation and proliferation |
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Authors: | T W Daughety P Marrack J W Kappler J M Chiller |
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Institution: | 1. National Jewish Hospital and Research Center, Department of Medicine, 3800 East Colfax Avenue, Denver, Colorado 80206 USA;2. University of Colorado Health Sciences Center, Departments of Medicine, Microbiology, and Biophysics and Biochemistry, Denver, Colorado 80206 USA;3. Scripps Clinic and Research Foundation, Department of Immunology, La Jolla, California 92037 USA |
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Abstract: | To define the antigen-presenting capacity of alveolar macrophages (AM phi), their ability to activate antigen-specific T cells was determined. It was found that AM phi s are at least as potent as spleen cells at presenting alloantigen or soluble protein antigen plus I-region determinant to cloned T-cell hybridomas. Activation of those hybridomas, shown by interleukin 2 (IL-2) secretion, further indicated the presence on AM phi s of functional products of the I-A and I-E subregions. In addition, it was found that AM phi s are at least as potent as spleen cells and peritoneal macrophages at inducing, in a restricted fashion, specific proliferation of primed, propagated lymph node T cells. AM phi s are thus potent accessory cells in vitro, whose in vivo significance in this capacity remains to be defined. |
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