Solid-phase synthesis of 1,3,4-oxadiazoline-5-thione derivatives from resin-bound acylhydrazines |
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| Authors: | Liu Zhanxiang Zhao Jinlong Huang Xian |
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| Institution: | Department of Chemistry, Zhejiang University (Campus Xixi), Hangzhou 310028, People's Republic of China. liuzhanx@zju.edu.cn |
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| Abstract: | A new strategy for solid-phase synthesis of 2,5-disubstituted 1,3,4-oxadiazoles has been developed. The 1,3,4-oxadiazoline-5-thione derivatives were synthesized from resin-bound acylhydrazines in several steps providing 78-88% overall yields and excellent purity. |
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