TNF-alpha and IL-12: a balancing act in macrophage functioning |
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| Authors: | Ma X |
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| Institution: | Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA. xim2002@med.cornell.edu |
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| Abstract: | Tumor necrosis factor alpha (TNF-alpha) and interleukin 12 (IL-12) are two major macrophage-derived mediators of inflammatory responses in mammals. Increasing evidence suggests that TNF-alpha is a double-edged sword with both proinflammatory and anti-inflammatory propensities. This article discusses the inter-regulation of TNF-alpha and IL-12 and the impact on the function of macrophages in innate and adaptive immunity. |
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