Association of Left Ventricular Mass with All-Cause Mortality,Myocardial Infarction and Stroke |
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Authors: | Alberto Bouzas-Mosquera Francisco J. Broullón Nemesio álvarez-García Jesús Peteiro Víctor X. Mosquera Alfonso Castro-Beiras |
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Affiliation: | 1. Department of Cardiology, Hospital Universitario A Coruña, A Coruña, Spain.; 2. Spanish Cooperative Cardiovascular Disease Research Network (RECAVA) - Instituto de Salud Carlos III, Madrid, Spain.; 3. Department of Information Technology, Hospital Universitario A Coruña, A Coruña, Spain.; 4. Department of Cardiac Surgery, Hospital Universitario A Coruña, A Coruña, Spain.; College of Pharmacy, University of Florida, United States of America, |
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Abstract: | BackgroundOur aim was to assess the association of left ventricular mass with mortality and nonfatal cardiovascular events.Methodology/Principal FindingsLeft ventricular mass was measured by echocardiography in 40138 adult patients (mean age 61.1±16.4 years, 52.5% male). The primary endpoint was all-cause mortality. Secondary endpoints included nonfatal myocardial infarction and nonfatal stroke. During a mean follow-up period of 5.6±3.9 years, 9181 patients died, 901 patients had a nonfatal myocardial infarction, and 2139 patients had a nonfatal stroke. Cumulative 10-year mortality was 26.8%, 31.9%, 37.4% and 46.4% in patients with normal, mildly, moderately and severely increased left ventricular mass, respectively (p<0.001). Ten-year rates of nonfatal myocardial infarction and stroke ranged from 3.2% and 6.7% in patients with normal left ventricular mass to 5.3% and 12.7% in those with severe increase in left ventricular mass, respectively. After multivariate adjustment, left ventricular mass remained an independent predictor of all-cause mortality (hazard ratio [HR] per 100 g increase 1.21, 95% confidence interval [CI] 1.14–1–27, p<0.001 in women, and HR 1.09, 95% CI 1.04–1–13, p<0.001 in men), myocardial infarction (HR 1.60, 95% CI 1.31–1.94, p<0.001 in women and HR 1.15, 95% CI 1.02–1.29, p = 0.019 in men) and stroke (HR 1.26, 95% CI 1.13–1.40, p<0.001 in women and HR 1.19, 95% CI 1.09–1.30, p<0.001 in men).Conclusions/SignificanceLeft ventricular mass has a graded and independent association with all-cause mortality, myocardial infarction and stroke. |
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