Human “Orchestrator” CD11b+ B1 Cells Spontaneously Secrete Interleukin-10 and Regulate T-Cell Activity |
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| Authors: | Daniel O Griffin Thomas L Rothstein |
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| Institution: | 1.Elmezzi Graduate School of Molecular Medicine, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America;2.Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America;3.Departments of Medicine and of Molecular Medicine, Hofstra North Shore–Long Island Jewish (LIJ) School of Medicine, Manhasset, New York, United States of America |
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| Abstract: | Immune regulation produced by B cells has been attributed to production and secretion of interleukin (IL)-10, which is a characteristic of mouse B1 cells. In view of the widespread clinical use of B-cell depletion therapies in autoimmune and malignant diseases, it is important to monitor the function and fate of regulatory B cells. However, there is no consensus regarding the phenotypic identity of human IL-10+ B cells. Here we show that human CD11b+ B1 cells, one of two recently described subpopulations of B1 cells, spontaneously produce IL-10 and suppress T-cell activation. In view of the capacity of these B cells to either stimulate T-cell proliferation or suppress T-cell activation, CD11b+ B1 cells are considered to be capable of orchestrating elements of immune responsiveness and thus are termed “orchestrator B1 cells,” or “B1orc,” whereas CD11b− B1 cells that primarily secrete antibody are termed “secretor B1 cells,” or “B1sec.” |
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