Aqueous humor nitric oxide in patients with central retinal vein occlusion |
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| Authors: | Masoud Aghsaei Fard Alireza Lashey Ahmad-reza Dehpour |
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| Institution: | a Farabi Eye Research Center, Department of Neuroophthalmology, Tehran University of Medical Sciences, Tehran, Iran;b Department of Pharmacology, Tehran University of Medical Science, Tehran, Iran |
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| Abstract: | PurposeIt has been suggested that nitric oxide (NO) has a role in ischemic retinopathies. Since retinal ischemia may develop in retinal vein occlusion, we investigated the presence of nitric oxide in the pathogenesis of central retinal vein occlusion (CRVO).MethodsEighteen consecutive patients with CRVO were included in this study. Aqueous humor specimens were obtained within 21 days of diagnosis. Samples of aqueous humor were also collected from 20 control patients undergoing cataract surgery. For each sample after reduction of nitrate to nitrite with vanadium chloride (VCl3), we used spectrophotometric method for simultaneous detection of nitrate and nitrite (NOx).ResultsMean level of aqueous humor NOx in CRVO and control group was 94.1 ± 23.2 μmol/l and 55.6 ± 11.0 μmol/l, respectively. The difference between two groups was statistically significant (p < 0.0001).ConclusionsOur results may support involvement of nitric oxide in the pathogenesis of CRVO. |
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| Keywords: | Nitric oxide Central retinal vein occlusion Spectrophotometry |
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