Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells |
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| Authors: | Nakaya Mako Onda Hiroyuki Sasaki Kyoko Yukiyoshi Akiko Tachibana Hirofumi Yamada Koji |
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| Institution: | Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Japan. makorenu@agr.kyushu-u.ac.jp |
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| Abstract: | Royal jelly is known as a functional food containing many useful minerals. In this study, we found an anti-environmental estrogen activity of royal jelly. Bisphenol A (BPA) is an environmental estrogen that stimulates proliferation of human breast cancer MCF-7 cells. Royal jelly inhibited the growth-promoting effect of BPA on MCF-7 cells, even though it did not affect the proliferation of cells in the absence of BPA. In addition, this inhibiting effect of royal jelly was heat-stable. |
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