The effect of halothane on mitochondrial permeability to NADH |
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| Authors: | M L Nahrwold J H Lecky P J Cohen |
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| Affiliation: | 1. Departments of Anesthesia University of Colorado School of Medicine Denver, Colorado 80220, USA;2. University of Pennsylvania School of Medicine Philadelphia, Pennsylvania 19104, USA |
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| Abstract: | The effect of halothane on oxidation of exogenous NADH was evaluated in intact and disrupted rat liver mitochondria. A change in oxygen uptake was observed which represented an interplay between inhibition of NADH dehydrogenase (tending to decrease respiratory rate) and loss of impermeability to NADH (tending to increase respiratory rate). |
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