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Indole-2-carboxamidines as novel NR2B selective NMDA receptor antagonists |
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| Authors: | Borza István Kolok Sándor Ignácz-Szendrei Györgyi Greiner István Tárkányi Gábor Galgóczy Kornél Horváth Csilla Farkas Sándor Domány György |
| Institution: | Gedeon Richter Ltd., Budapest, 10. PO Box 27, H-1475, Hungary |
| Abstract: | A novel series of indole-2-carboxamidine derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of the substituents on the indole skeleton as well as the substitution of the benzyl moiety on the biological activity of the compounds was studied. Compound 5a was po active in the formalin test in mouse. |
| Keywords: | Indole-2-carboxamidine NB2B NMDA |
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