Neutrophil microparticles modulate cytokine production by natural killer cells |
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| Affiliation: | 1. Department of Clinical Laboratory Medicine, Shanghai Tenth People''s Hospital of Tongji University, Shanghai 200072, China;2. Institute of Bioengineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China;3. Department of Central Laboratory, Shanghai Tenth People''s Hospital of Tongji University, Shanghai 200072, China;4. School of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China;5. Faculty of Medical Laboratory Science, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China |
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| Abstract: | Neutrophil microparticles (NMs) are scarce in the circulation but are highly enriched at sites of inflammation and exert profound effects on immune cells. In the present study, we addressed whether NMs modulate cytokine-producing capacity of natural killer (NK) cells. NMs inhibited the production of IFN-γ and TNF-α but enhanced the release of TGF-β1 by IL-2/IL-12-activated NK cells. The inhibitory effect of NMs was strongly attenuated by blockade of phosphatidylserine exposed on NMs. Thus, NMs skew the cytokine profile of NK cells from pro-inflammatory toward anti-inflammatory, potentially favoring the resolution of inflammation. |
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| Keywords: | Neutrophil microparticles NK cells Cytokines Phosphatidylserine |
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