New Metrics for Evaluating Viral Respiratory Pathogenesis |
| |
Authors: | Vineet D. Menachery Lisa E. Gralinski Ralph S. Baric Martin T. Ferris |
| |
Affiliation: | 1. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.; 2. Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.; 3. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.; Deutsches Primatenzentrum GmbH - Leibniz-Institut fur Primatenforschung, GERMANY, |
| |
Abstract: | Viral pathogenesis studies in mice have relied on markers of severe systemic disease, rather than clinically relevant measures, to evaluate respiratory virus infection; thus confounding connections to human disease. Here, whole-body plethysmography was used to directly measure changes in pulmonary function during two respiratory viral infections. This methodology closely tracked with traditional pathogenesis metrics, distinguished both virus- and dose-specific responses, and identified long-term respiratory changes following both SARS-CoV and Influenza A Virus infection. Together, the work highlights the utility of examining respiratory function following infection in order to fully understand viral pathogenesis. |
| |
Keywords: | |
|
|