Case-control study of rhinoconjunctivitis associated with IL5RA polymorphisms in Japanese women: The Kyushu Okinawa Maternal and Child Health Study |
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| Institution: | 1. Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan;2. Health Tourism Research Center, Graduate School of Tourism Sciences, University of the Ryukyus, Okinawa, Japan;1. Department of Surgery, Loyola University Chicago, Stritch School of Medicine, United States;2. Department of Molecular Pharmacology & Therapeutics, Loyola University Chicago, Stritch School of Medicine, United States;3. Department of Biochemistry, Medical College of Wisconsin, United States;1. Department of Pathology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA;2. Department of Microbiology and Parasitology, College of Basic Medical Sciences, China Medical University, Shenyang 110001, China;3. Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA;4. Department of Microbiology and Immunology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA;1. Department of Molecular Biology and Biotechnology, Tezpur University, Napaam, Tezpur 784028, Assam, India;2. Department of Medicine, Assam Medical College & Hospital, Lila Gogoi Path, Dibrugarh 786002, Assam, India;1. School of Nursing, University of Pittsburgh, 3500 Victoria Street, Pittsburgh, PA 15261, United States;2. School of Nursing, University of California, San Francisco, 2 Koret Way, Box 0610, San Francisco, CA 94143, United States;3. Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Avenue, Box 0794, San Francisco, CA 94143, United States;4. School of Medicine, University of California, San Francisco, 513 Parnassus Avenue, Box 0410, San Francisco, CA 94143, United States;5. Redwood Regional Medical Group, 121 Sotoyome Street, Santa Rosa, CA 95405, United States;1. INSERM U995, Université de Lille, Lille, France;2. EA 2686, Université de Lille, Lille, France;3. Department of Otorhinolaryngology–Head and Neck Surgery, University Hospital, Lille, France;4. French Eosinophil Network, University Hospital, Lille, France;1. Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA;2. Division of Preventative Medicine, University of Alabama at Birmingham, Birmingham, AL, USA;3. Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA;4. Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, USA |
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| Abstract: | BackgroundEpidemiological research on the relationship between single nucleotide polymorphisms (SNPs) in the IL5RA gene and allergic disorders is limited. We examined the relationship between IL5RA SNPs and risk of rhinoconjunctivitis in young adult Japanese women.MethodsIncluded were 393 women who met the criteria of the International Study of Asthma and Allergies in Childhood (ISAAC) for rhinoconjunctivitis. Controls were 767 women without rhinoconjunctivitis according to the ISAAC criteria who had not been diagnosed with allergic rhinitis by a doctor. Adjustment was made for age, region of residence, presence of older siblings, smoking, and education.ResultsCompared with the CC genotype of SNP rs6771148, the CG genotype, but not the GG genotype, was significantly associated with a reduced risk of rhinoconjunctivitis: the adjusted OR for the CG genotype was 0.76 (95% CI: 0.58–0.99). No evident associations were found between SNPs rs17882210, rs3804797, rs334809, rs9831572, or rs17881144 and rhinoconjunctivitis. The ACTAGA haplotype of rs17882210, rs3804797, rs334809, rs9831572, rs6771148, and rs17881144 was significantly inversely associated with rhinoconjunctivitis (crude OR = 0.58, 95% CI: 0.37–0.88) while the GTAGCA haplotype was significantly positively related to rhinoconjunctivitis (crude OR = 1.74, 95% CI: 1.14–2.65). No significant interactions affecting rhinoconjunctivitis were observed between any of the six SNPs and smoking.ConclusionThis is the first study to show significant associations between IL5RA SNP rs6771148, the ACTAGA haplotype, and the GTAGCA haplotype and the risk of rhinoconjunctivitis. We did not find evidence for interactions affecting rhinoconjunctivitis between any of the IL5RA SNPs and smoking. |
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| Keywords: | Japanese women Polymorphism Rhinoconjunctivitis Smoking |
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